We are excited to announce that a preliminary version of the program for the third conference will be available soon.
Meanwhile, if you want to know a little bit more about the conference and how it works, you can take a look at the program of the last edition.
We are working hard to provide you with an enriching and inspiring event, featuring prominent speakers and relevant topics. You won’t want to miss it!
| May 22nd, 2025 | |
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| 8:00 AM | Registration |
| 8:30 AM | Welcome and Life Achievement Award · Juan Fortea. Memory Unit Director. Hospital of Sant Pau; Barcelona, Spain · Heather Snyder. Alzheimer’s Association; Chigaco, USA · Carla Obradors-Tarragó. Fundació Pasqual Maragall, Hub Alzheimer Barcelona, Spain · Katy Trias. CEO of Catalan Down Syndrome Foundation; Barcelona, Spain · Alberto Lleó. Chair of Neurology. Hospital of Sant Pau; Barcelona, Spain · Raquel Sánchez-Valle. AD and Other cognitive disorders Group leader. Hospital Clínic de Barcelona. IDIPABS; Barcelona, Spain |
| 9:00 AM | Oral Sessions 1: Basic Science Moderators: Heather Snyder and Marie-Claude Potier 1. Vascular remodeling and blood-brain barrier breakdown in individuals with Down syndrome and Alzheimer’s disease Lisi Flores Aguilar. University of California; Irvine, USA 2. Genetic modifiers of age at onset of Alzheimer’s Disease in APP Duplications and Down Syndrome Joan Groeneveld. Amsterdam UMC, Alzheimer Center Amsterdam; Amsterdam, The Netherlands 3. Age and sex influence Alzheimer’s disease neuropathology in Down syndrome leading to regional differences Elizabeth Andrews. University of California; Irvine, USA 4. Neuropathological alterations of the locus coeruleus in Down syndrome compared to other neurodegenerative diseases Marie-Claude Potier. Institut du Cerveau; Paris, France |
| 10:30 AM | Coffee Break / Networking |
| 11:00 AM | Oral Session 2: Clinical / Neuropsychological Moderators: Jason Hassenstab and Sigan Hartley 1. Discrepancies in Assessing Intellectual Disability Levels in Adults with Down syndrome: Implications for Dementia Diagnosis Katja Sandkühler. Department of Neurology, LMU University Hospital, LMU Munich; Munich, Germany 2. Impact of Genetic Testing for Familial Dementia: Experiences of Patients and Families Jetske Van der Schaar. Amsterdam UMC, Alzheimer Center Amsterdam; Amsterdam, The Netherlands 3. Factors Influencing Survival in Adults with Down Syndrome and Alzheimer’s Disease Bessy Benejam. Fundació Catalana Síndrome de Down; Barcelona, Spain 4. Using machine learning to identify novel predictors of Down syndrome Alzheiemer dementia Eric Rubenstein. Boston University; Boston, USA |
| 12:30 PM | Lunch and Poster Session 1 Poster presentations with authors available for informal discussions |
| 2:00 PM | Oral Session 3: Fluid Biomarkers Moderators: Johannes Levin and María Carmona 1. Alpha-Synuclein co-pathology in Down Syndrome-Associated Alzheimer’s: Findings from Seed Amplification and Neuropathology Íñigo Rodríguez Baz. Sant Pau Memory Unit, Biomedical Research Institute Sant Pau (IIB SANT PAU); Barcelona, Spain 2. A Decade of Insights: The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and Its Impact on Alzheimer’s Disease in Down Syndrome Laura Videla. Hospital of Sant Pau; Barcelona, Spain 3. Validation of Amyloid Chronicity in Autosomal Dominant Alzheimer Disease Julie Wisch. Washington University Medical School; St. Louis, USA 4. The effect of APOEE4 on amyloid accumulation and tau phosphorylation in adults with Down Syndrome Omar Abdelmoity. Washington University in St. Louis ; St. Louis, USA |
| 3:30 PM | Coffee Break / Networking |
| 4:00 PM | Symposium 1: What is genetically determined Alzheimer’s disease? Should we consider including new forms? Moderators: Raquel Sánchez-Valle and Alberto Lleó Speakers: · John Hardy. UCL; London, UK. · Juan Fortea. Hospital of Sant Pau; Hub Alzheimer Barcelona Barcelona, Spain. |
| 5:30 PM | End of Day 1 |
| 8:30 PM | Gala dinner (registration required) at Restaurant Barceloneta (Moll dels Pescadors, Port Vell, Carrer de l’Escar, 22. Barcelona) |
| May 23rd, 2025 | |
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| 9:00 AM | Oral Session 4: Neuroimaging (or other biomarkers) Moderators: Beau Ances and Natalie Ryan 1. Cortical Asymmetry Index in Autosomal Dominant Alzheimer’s Disease: Findings from the Clínic Barcelona and the DIAN Cohorts Agnès Pérez-Millan. Hospital Clínic de Barcelona-IDIBAPS; Barcelona, Spain 2. Peripheral Retinal and Choroidal Vascular Changes in Down Syndrome: Insights into Early Alzheimer’s Disease Pathology? Lajos Csincsik. Queen’s University Belfast; Belfast, UK 3. PSMD as a Promising Biomarker for Early Identification of White Matter Integrity Changes in Down Syndrome Alejandra Morcillo-Nieto. Biomedical Research Institute Sant Pau; Barcelona, Spain 4. Brain Volume Trajectories in Down Syndrome and Autosomal Dominant Alzheimer James Kennedy. Washington University in St. Louis School of Medicine; St. Louis, USA |
| 10:30 AM | Coffee Break / Networking |
| 11:00 AM | Symposium 2: Clinical trials in ADAD & DSAD · Michael Rafii. University of Southern California; San Diego, USA · Eric McDade. Washington University; Sant Louis, USA |
| 12:30 PM | Lunch and Poster Session 2 New round of poster presentations with authors available for questions |
| 2:00 PM | Symposium 3. Making Research Participation Meaningful: Perspectives of Adults with Down syndrome and their Family Members Moderator: Sigan Hartley Speakers: · Greta Foye. KU Medical Center; Kansas, USA · Erika Foye. KU Medical Center; Kansas, USA · Danna Sciullo. National Down Syndrome Society; Butler, USA · Laia Hamzaoui. Hospital de la Santa Creu i Sant Pau; Barcelona, Spain · Angela Revuelta Salmeron. Hospital de la Santa Creu i Sant Pau; Barcelona, Spain · Sarah Walter. Alzheimer’s Therapeutic Research Institute, University of Southern California; San Diego, USA · Matthew Janicki. University of Illinois Chicago; Rockport, USA · Ann Cohen. University of Pittsburgh School of Medicine; Clairton, USA |
| 3:00 PM | Closing remarks and summary of conference findings by conference organizers Raquel Sánchez-Valle, Juan Fortea |
| 3:30 PM | Coffee Break / Networking |
* Sessions are listed in Central European Standard Time (CEST). Schedule is current at the time of posting